Detalhe da pesquisa
1.
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.
Nature
; 593(7859): 429-434, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34012082
2.
Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models.
Circulation
; 147(3): 242-253, 2023 01 17.
Artigo
Inglês
| MEDLINE | ID: mdl-36314243
3.
Spacer Fidelity Assessments of Guide RNA by Top-Down Mass Spectrometry.
ACS Cent Sci
; 9(7): 1437-1452, 2023 Jul 26.
Artigo
Inglês
| MEDLINE | ID: mdl-37521788
4.
GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy.
Nat Commun
; 14(1): 2776, 2023 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37188660
5.
Cerebrospinal fluid can be used as a surrogate to assess brain exposures of breast cancer resistance protein and P-glycoprotein substrates.
Drug Metab Dispos
; 40(4): 779-87, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22266779
6.
Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.
Bioorg Med Chem Lett
; 21(24): 7277-80, 2011 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22061640
7.
Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.
Bioorg Med Chem Lett
; 20(7): 2264-9, 2010 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20188554
8.
Discovery of a Novel Cabazitaxel Nanoparticle-Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a ß-Cyclodextrin-PEG Copolymer Based Delivery Platform.
J Med Chem
; 62(21): 9541-9559, 2019 11 14.
Artigo
Inglês
| MEDLINE | ID: mdl-31593466
9.
Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration.
Fluids Barriers CNS
; 15(1): 10, 2018 Mar 20.
Artigo
Inglês
| MEDLINE | ID: mdl-29558954
10.
Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction.
Sci Rep
; 8(1): 13438, 2018 09 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30194389
11.
A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing.
Cell Rep
; 22(9): 2227-2235, 2018 02 27.
Artigo
Inglês
| MEDLINE | ID: mdl-29490262
12.
Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle-Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer.
Cancer Res
; 76(15): 4493-503, 2016 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27325647
13.
BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aß isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.
Neuropharmacology
; 103: 57-68, 2016 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-26690893
14.
MARS: bringing the automation of small-molecule bioanalytical sample preparations to a new frontier.
Bioanalysis
; 4(11): 1311-26, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22720650
15.
Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.
ACS Med Chem Lett
; 2(10): 786-91, 2011 Oct 13.
Artigo
Inglês
| MEDLINE | ID: mdl-24900267
16.
A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity.
MAbs
; 3(3): 273-88, 2011.
Artigo
Inglês
| MEDLINE | ID: mdl-21393993
17.
Biomarker discovery in rat plasma for estrogen receptor-alpha action.
Electrophoresis
; 26(23): 4486-94, 2005 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-16315174
18.
Automated protein identification using atmospheric-pressure matrix-assisted laser desorption/ionization.
Rapid Commun Mass Spectrom
; 17(14): 1600-10, 2003.
Artigo
Inglês
| MEDLINE | ID: mdl-12845586